First Author      Title     Journal Year       DOI PubMed
Multigner, L. Pancreatic stone protein, a phosphoprotein which inhibits calcium carbonate precipitation from human pancreatic juice carbonate precipitation from human pancreatic juice. Biochemical & Biophysical Research Communications 1983   6838525
Gross, J. An unusual bovine pancreatic protein exhibiting pH-dependent globule-fibril transformation and unique amino acid sequence. PNAS 1985   3862086
Gross, J. Isolation, characterization, and distribution of an unusual pancreatic human secretory protein. Journal of Clinical Investigation 1985   3908481
Montalto, G.  Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein Biochemical Journal 1986   3541906
Lechene de la Porte, P. Immunocytochemical localization of pancreatic stone protein in the human digestive tract Pancreas 1986   3550781
De Caro, A. M.  Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice FEBS 1987   3665916
Rouimi, P. Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein FEBS Letters 1987   3108036
Terazono, K. A novel gene activated in regenerating islets Journal of Biological Chemistry 1988   2963000
Petersen, T. E.  The amino-terminal domain of thrombomodulin and pancreatic stone protein are homologous with lectins FEBS Letters 1988   2834230
Rouimi, P.  The disulfide bridges of the immunoreactive forms of human pancreatic stone protein isolated from pancreatic juice FEBS Letters 1988   3345835
Ozturk, M. Elevated levels of an exocrine pancreatic secretory protein in Alzheimer disease brain PNAS 1989   2463628
Watanabe, T. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene Journal of Biological Chemistry 1990   2332435
Sarles, H. Renaming pancreatic stone protein as 'lithostathine'. Gastroenterology 1990   2379794
De la Monte, S. M. Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain Journal of Clinical Investigation 1990   2394826
Yamadera, K. Identification of immunoreactive pancreatic stone protein in pancreatic stone, pancreatic tissue, and pancreatic juice Pancreas 1990   2111547
Senegas-Balas, F. O. Immunocytochemical demonstration of a pancreatic secretory protein of unknown function in human duodenum Journal of Histochemistry & Cytochemistry 1991   1865108
Bernard, J. P. Immunoreactive forms of pancreatic stone protein in six mammalian species Pancreas 1991   1886885
Rouquier, S. Rat pancreatic stone protein messenger RNA. Abundant expression in mature exocrine cells, regulation by food content, and sequence identity with the endocrine reg transcript Journal of Biological Chemistry 1991   1985964
Vinik, A.I. Factors controlling pancreatic islet neogenesis.  The Yale Journal of Biology and Medicine 1992   1364089
Iovanna, J. Lithostathine, an inhibitor of CaCO3 crystal growth in pancreatic juice, induces bacterialaggregation. Pancreas 1993   8302796
Dusetti, N. J. Rapid PCR cloning and sequence determination of the rat lithostathine gene Biochimica et Biophysica Acta 1993   7916640
Unno, M. Structure, chromosomal localization, and expression of mouse reg genes, reg I and reg II. A novel type of reg gene, reg II, exists in the mouse genome Journal of Biological Chemistry 1993   8340418
De Reggi, M. The glycan moiety of human pancreatic lithostathine. Structure characterization and possiblepathophysiological implications FEBS 1995   7607222
Bimmler, D. High-level secretion of native rat pancreatic lithostathine in a baculovirus expression system Pancreas 1995 10.1097/00006676-199507000-00007. 7667245
Geider, S. Pancreatic lithostathine as a calcite habit modifier Journal of Biological Chemistry 1996   8824282
Zenilman, M.E. Pancreatic regeneration (reg) gene expression in a rat model of islet hyperplasia.  Surgery  1996   8619215
Dusetti, N. J. Induction of lithostathine/reg mRNA expression by serum from rats with acute pancreatitis and cytokines in pancreatic acinar AR-42J cells Archives of Biochemistry & Biophysics 1996   8651687
Apte, M. V. Both ethanol and protein deficiency increase messenger RNA levels for pancreatic lithostathine Life Sciences 1996   8569421
Zenilman, M. E. Pancreatic thread protein is mitogenic to pancreatic-derived cells in culture Gastroenterology 1996   8613011
Bimmler, D. Pancreatic stone protein (lithostathine), a physiologically relevant pancreatic calcium carbonatecrystal inhibitor? Journal of Biological Chemistry 1997 10.1074/jbc.272.5.3073. 9006958
Kato, M. Change of pancreatic enzymes, pancreatic stone protein (PSP), and plasma alpha(2)-macroglobulin-trypsin complex-like substance (MTLS) in the activation of pancreatic juice Pancreas 1997   9361087
Zenilman, M. E.  Effect of reg protein on rat pancreatic ductal cells Pancreas 1998   9788538
De Reggi, M. Lithostathine, the presumed pancreatic stone inhibitor, does not interact specifically with calcium carbonate crystals. Journal of Biological Chemistry 1998   9478942
Zhang, Z.  Proteasome activation by REG molecules lacking homolog-specific inserts Journal of Biological Chemistry 1998   9545278
Renugopalakrishnan, V. Human pancreatic thread protein, an exocrine thread protein with possible implications to Alzheimer's disease: secondary structure in solution at acid pH Biochemical & Biophysical Research Communications 1999   10329440
Cerini, C. Biophysical characterization of lithostathine. Evidences for a polymeric structure at physiological pH and a proteolysis mechanism leading to the formation of fibrils Journal of Biological Chemistry 1999   10428794
Rechreche, H.  pap, reg Ialpha and reg Ibeta mRNAs are concomitantly up-regulated during human colorectal carcinogenesis International Journal of Cancer 1999   10328217
Bimmler, D. Regulation of PSP/reg in rat pancreas: immediate and steady-state adaptation to different diets Pancreas 1999  10.1097/00006676-199910000-00006. 10505756
Gerbaud, V. Mechanism of calcite crystal growth inhibition by the N-terminal undecapeptide of lithostathine Journal of Biological Chemistry 2000   10625646
Zenilman, M. E.  Comparison of reg I and reg III levels during acute pancreatitis in the rat Annals of Surgery 2000   11066135
Yamaoka, T. Diabetes and tumor formation in transgenic mice expressing Reg I Biochemical & Biophysical Research Communications 2000   11097844
Gregoire, C. Three-dimensional structure of the lithostathine protofibril, a protein involved in Alzheimer's disease EMBO Journal 2001   11432819
Sanchez, D.  Preferential expression of reg I beta gene in human adult pancreas Biochemical & Biophysical Research Communications 2001   11396963
Graf, R. A family of 16-kDa pancreatic secretory stress proteins form highly organized fibrillar structures upon tryptic activation Journal of Biological Chemistry 2001 10.1074/jbc.M010717200. 11278730
Graf, R. Coordinate regulation of secretory stress proteins (PSP/reg, PAP I, PAP II, and PAP III) in the rat exocrine pancreas during experimental acute pancreatitis Journal of Surgical Research 2002 10.1006/jsre.2002.6387. 12121700
Lee, B. I. Characterization of calcium binding properties of lithostathine Journal of Biological Inorganic Chemistry 2003   12589570
Meili, S.  Secretory apparatus assessed by analysis of pancreatic secretory stress protein expression in a rat model of chronic pancreatitis Cell & Tissue R. 2003 10.1007/s00441-003-0733-1. 12764608
Laurine, E.  Lithostathine quadruple-helical filaments form proteinase K-resistant deposits in Creutzfeldt-Jakob disease Journal of Biological Chemistry 2003   13129929
Sanchez, D.  Implication of Reg I in human pancreatic duct-like cells in vivo in the pathological pancreas and in vitro during exocrine dedifferentiation Pancreas 2004   15211106
Bimmler, D. Coordinate regulation of PSP/reg and PAP isoforms as a family of secretory stress proteins in an animal model of chronic pancreatitis Journal of Surgical Research 2004 10.1016/S0022-4804(03)00342-1. 15100001
Hu, L. Two-dimensional protein database of human pancreas Electrophoresis 2004   14760645
Takasawa, S. Cyclin D1 activation through ATF-2 in Reg-induced pancreatic beta-cell regeneration FEBS Letters 2006   16405968
Steele, I. A. Helicobacter and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements American Journal of Physiology - Gastrointestinal & Liver Physiology 2007   17463184
Sekikawa, A. REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells Carcinogenesis 2008   18024479
Mueller, C. M. Pancreatic reg I binds MKP-1 and regulates cyclin D in pancreatic-derived cells Journal of Surgical Research 2008   18929742
Yamauchi, A.  Thiazolidinediones inhibit REG Ialpha gene transcription in gastrointestinal cancer cells Biochemical & Biophysical Research Communications 2009   19118520
Usami, S.  Regenerating gene I regulates interleukin-6 production in squamous esophageal cancer cells Biochemical & Biophysical Research Communications 2010   20056108
Milhiet, P. E. Deciphering the structure, growth and assembly of amyloid-like fibrils using high-speed atomic force microscopy PLoS ONE 2010   20949034
Ling, L. PSP/reg inhibits cultured pancreatic stellate cell and regulates MMP/TIMP ratio European Journal of Clinical Investigation 2011 10.1111/j.1365-2362.2010.02390.x. 20860757
Marchal, S.  Distribution of lithostathine in the mouse lemur brain with aging and Alzheimer's-like pathology Neurobiology of Aging 2012   21371784
Acquatella-Tran Van Ba, I. Regenerating islet-derived 1 (Reg-1) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor Journal of Biological Chemistry 2012   22158612
Ho, M. R. 1H, 13C, and 15N resonance assignments for human regenerating family I protein Biomolecular NMR Assignments 2012   21918816
Calderari, S. Regenerating 1 and 3b Gene Expression in the Pancreas of Type 2 Diabetic Goto-Kakizaki (GK) Rats PLoS One 2014   24587207
Perez-Vazquez, V. Differential proteomic analysis of the pancreas of diabetic db/db mice reveals the proteins involved in the development of complications of diabetes mellitus International Journal of Molecular Sciences 2014   24886809
Coffey, Richard Microarray Analysis of Rat Pancreas Reveals Altered Expression of Alox15 and Regenerating Islet-Derived Genes in Response to Iron Deficiency and Overload PLoS One 2014   24465846
Yamauchi, A. Synergistic activations of REG I alpha and REG I beta promoters by IL-6 and Glucocorticoids through JAK/STAT pathway in human pancreatic beta cells Journal of Diabetes Research 2015   25767811
Chai, Y. R. Investigating the role of introns in the regulation of regenerating gene 1 expression Oncology Letters 2015   25621062
Xu, W. Regenerating islet-derived protein 1 inhibits the activation of islet stellate cells isolated from diabetic mice Oncotarget 2015   26496027
Cuadrado, A. The contribution of cohesin-SA1 to gene expression and chromatin architecture in two murine tissues Nucleic Acids Research 2015   25735743
Lepage, D. Identification of GATA-4 as a novel transcriptional regulatory component of regenerating islet-derived family members Biochimica et Biophysica Acta 2015   26477491
Sun, C. Expression of Reg family genes in the gastrointestinal tract of mice treated with indomethacin American Journal of Physiology - Gastrointestinal & Liver Physiology 2015   25747353
Reding, T. The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP/regI and PAP/regIII Oncotarget 2017 10.18632/oncotarget.16282. 28415799
Stone, S. Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells. Scientific reports 2019 10.1038/s41598-019-41604-4. 30914711
Graf, R. Pancreatic stone protein - sepsis and the riddles of the exocrine pancreas Pancreatology 2020 10.1016/j.pan.2020.01.016 32037128